What are the side effects of Zithromax and other drugs that have azithromycin as the main active substance?
- On the part of the digestive system: nausea, vomiting, diarrhea, abdominal pain, diarrhea, flatulence, indigestion, anorexia, constipation, discoloration of the tongue, pseudomembranous colitis, cholestatic jaundice, hepatitis, changes in laboratory parameters of liver function, liver failure, liver necrosis (possibly fatal).
- Allergic reactions: itching, skin rash, angioedema, urticaria, photosensitivity, anaphylactic reaction (in rare cases with fatal outcome), erythema multiforme, Stevens-Johnson syndrome, toxic epidermal scrolysis.
- From the side of cardiovascular system: feeling of heartbeat, arrhythmia, ventricular tachycardia, prolongation of QT interval, bidirectional ventricular tachycardia.
- Nervous system disorders: dizziness / vertigo, headache, convulsions, drowsiness, paresthesia, asthenia, insomnia, hyperactivity, aggressiveness, anxiety, nervousness.
- From the circulatory and lymphatic systems: thrombocytopenia, neutropenia, eosinophilia.
- From the musculoskeletal system: arthralgia.
- On the part of the urogenital system: interstitial nephritis, acute renal failure.
- Other: vaginitis, candidiasis.
Are There Any Possible Complications
Complications of Zithromax (azithromycin) may occur if the patient takes the medicine without a doctor’s prescription, without having carefully studied the annotation to the drug. Many are accustomed to taking antibiotics three times a day for a course of 5-10 days, but this does not apply to azithromycin. Such a technique will necessarily lead to an overdose of azithromycin and related complications.
Overdose of Zithromax (azithromycin) can be manifested by the following symptoms:
- Disorders of the digestive tract (dilution of stool, feeling of pain in the abdomen, vomiting, nausea, deterioration of the liver);
- Nervous system problems (hearing impairment).
If a patient or doctor suspects that an azithromycin overdose has occurred, then it is necessary to take the following measures: flush the stomach, give plenty of water to the patient, and give intestinal sorbents.
How to Take the Drug Safely
The use of Zithromax based on azithromycin is determined by the doctor depending on the severity of the infection and the nature of the infection process. For infectious diseases of the eye, eye drops are used in the conjunctival sac. Most often, azithromycin is administered orally, that is, through the mouth. However, in some cases, when the infection is severe or the use of drugs through the mouth is impossible, azithromycin is administered intravenously.
When treating with a medicine containing azithromycin, it is necessary to ensure that the intake does not coincide with meals. It is best if the patient takes it 1 hour before or 2 hours after eating. You can either disperse a tablet or drink it with water, or dissolve it in a small amount of water (mix and drink). It is recommended to drink a suspension, tablet or capsule with a small amount of water. The tablet is not necessary to chew, the capsule does not need to open.
How to prepare a suspension for children is described in detail in the annotation to the medicine. Pure drinking water is used to dilute the powder. The suspension should be shaken before taking. To prepare the solution for infusion, first vial of the drug is diluted in sterile water for injection. This is how the reconstituted solution is prepared. Then the reconstituted solution must be diluted to the desired concentration using a physiological solution, glucose solution 5% or Ringer’s solution. How to properly dilute azithromycin for intravenous administration (the ratio of substances) is described in detail in the annotation to the drug.
Contraindications to the Intake of Zithromax
Contraindications to the use of azithromycin must be determined before the patient is prescribed the drug. Most contraindications to the use of azithromycin can be determined easily by a doctor, but the patient must warn about some of them himself. Currently, the following contraindications to the use of azithromycin (and other antibiotics of this group) are indicated:
- Increased sensitivity to both azithromycin itself and additional components of the drug;
- Severe diseases of the liver and / or kidneys, which are accompanied by a serious violation of their functions;
- Fructose intolerance, isomaltase / sucrase deficiency, glucose and galactose absorption disorders; In children and adolescents under 16 for intravenous use of the drug;
- In children under 12 years old (weight up to 45 kg) while taking capsules and tablets; Children up to 6 months when taking suspension;
- Simultaneous medication with ergotamine or dihydroergotamine. The manufacturer also points to the following restrictions for taking the drug: liver and/or kidney dysfunction;
- Heart rhythm disturbances or predisposition to arrhythmias, as well as lengthening of the QT interval (this can be found out after deciphering an electrocardiogram — ECG).
Does Zithromax Have Any Influence on the Ability to Drive
Does Zithromax influence the patient’s ability to drive and work with machinery? To date, no negative effect of azithromycin on this ability has been identified. According to the instructions for the drug, driving and working with mechanisms is not prohibited. However, there are side effects of the drug, such as impaired vision, hearing, dizziness, etc. If such symptoms prevent the patient from working with the mechanisms or driving a car, it is worthwhile to postpone this work until recovery and full restoration of impaired body functions.
How to Store the Drug the Right Way
If the storage conditions of Zithromax (azithromycin) are not respected, the drug will not only lose its properties, but may also be dangerous to the patient’s health. Azithromycin shelf life varies greatly depending on the dosage form. Thus, the shelf life of the drug in tablets and capsules is from 2 to 5 years. It is very important to carefully read the annotation for each medication and not to throw away the packaging, which indicates the expiration date of the drug. If the expiration date is not visible or is not clearly indicated, then it is better not to use such a drug for treatment.